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2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine is a synthetic chemical compound belonging to the pyrido[2,3-d]pyrimidine class of molecules. It functions as an inhibitor of dihydrofolate reductase (DHFR), an enzyme crucial for folate metabolism and DNA synthesis. This mechanism of action suggests its potential as an antineoplastic agent, as evidenced by preclinical studies on similar trimethoxy-substituted analogues showing potent inhibition of tumor cell growth.
- Other names
- 5-methyl-6-([methyl(3,4,5-trimethoxyphenyl)amino]methyl)pyrido[2,3-d]pyrimidine-2,4-diamine
02
Targets
DHFR (Dihydrofolate reductase)
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